In the year 1889, a man by the name of Charles Brown-Sequard decided to inject himself with macerated dog testicles as well as monkey glands on several occasions. His claims were that he actually felt better. I, among many others, highly doubt his testimonials.
Sir Arthur Ignatius Conan Doyle, the famous Scottish physician and writer, had also written one of his Sherlock Holmes books about "The Adventure of the Creeping Man".
John Romulus Brinkley, an American, was apparently a "specialist in rejuvenation", or so he claims to have been. He was interested in the horny nature of goats. His claims were that there were effects that resulted from the insertion of goat testicle parts into men, of which several of such tests were actually conducted. Needless to say, none of these ridiculous trials had any actual affect!
Image source: Wikipedia.com
We come to the year 1895, where adrenalin was extracted and injected into animals which showed signs of increased blood pressure.
I will continue my discussion in my next few blog posts, where I will begin to explain more on the role of hormones and less about the past history of this discovery.